A recent study with mice suggests NAD+ repletion with niacin counteracts cancer cachexia. The study published in Nature Communications implies that NAD+ repletion, using vitamin B3 niacin, efficiently corrects tissue NAD+ levels. Therapy that was used in cachectic mice also improved mitochondrial metabolism, and ameliorated cancer- and chemotherapy-induced cachexia. To detect the NAD+ levels in mice researchers used NADMED technology. Overall, the results propose NAD+ metabolism as a therapy target for cachectic cancer patients. You can read the article here.