Exposure to cold is known to cause changes in NAD+ precursors which are associated with brown adipose tissue (BAT) activation. A recent study reveals the mechanism behind the phenomenon. Researchers conclude that NAD+ metabolism is activated upon cold in humans through changes in serum levels of the NAD+ precursor metabolites NAM, tryptophan, and kynurenine, and is probably regulated in a coordinated fashion by several tissues. NADMED was used as one of the research tools. Read more here.