NADMED answers to demand

NAD measurement has been performed using mass spectrometry or colorimetric kits. Each method involves a set of characteristic problems. Using a mass spectrometer is expensive and time-consuming, while the colorimetric kits on the market are inaccurate and unreliable. The NADMED method solves these problems, providing a fast, accurate, and reliable method for the cost-effective measurement of NADs. Q-NADMED kits measure all four forms of NAD (NAD+, NADH, NADP+, and NADPH) and glutathiones. No other method can do this.

Due to its accuracy and reliability, the Q-NADMED Kit is CE-marked for measuring NAD+ and NADH from a small blood sample for a range of clinical purposes. The marking indicates the kit complies with the European Union (EU) In Vitro Diagnostic Medical Devices Directive (IVDD 98/79/EC) and that the device may be brought to market in the EU. The Q-NADMED Kit is the only kit for the NAD measurement to have received CE-marking.

Because of its ease of use, speed, and scalability, NADMED technology allows NADs to be measured at the population level – accelerating and expanding NAD research into developing a targeted treatment for NAD-related conditions and diseases. Home testing is not yet possible, but those interested in their own NAD levels are encouraged to contact their local medical services.

Key advantages of NADMED technology

1. Ability to measure all four forms of NAD and two glutathiones

Accessing all six REDOX metabolites helps one gain more information on the biology of NAD and glutathione than any other means, which is crucial to researchers as they can develop novel associations and predictive scores based on multiple biomarkers. Subsequent use of such data in clinical applications is expected to increase dramatically in the near future.

2. Throughput

The NADMED measurements are high throughput, enabling high-volume clinical and consumer services and studying even the largest clinical trials or biobank cohorts.

3. Low hands-on time (kit)

Measurements with NADMED technology can be rapidly performed. Whereas mass spectrometry requires an hour or more of working time per sample, the corresponding figure for NADMED measurement time is approximately two minutes, considerably reducing the personnel costs associated with measuring NADs and improving efficiency, enabling the handling of thousands of samples in a matter of days.

4. No need to invest in specialized equipment

Most clinical laboratories do not need to invest in new equipment to perform the NADMED measurement because common, affordable colorimetric readers suffice.

5. Accuracy

Results are accurate at all metabolite concentrations in all tested sample types. We have also created our own standards utilizing unique spectral features of NAD molecules.

6. Small sample volume

The NADMED measurements can be performed from a small sample volume (120 μL of whole blood), allowing for the efficient collection of samples from numerous individuals. These measurements are useful for biobanks, cohorts, and clinical trials because their sample material is limited and precious. Further, the small volume is valuable for animal studies, such as in mice, where the available blood volumes are small, and the sample is used to perform multiple analyses. Small sample volume is also a prerequisite for future at-home sampling.