A study involving a healthy population of 1162 individuals revealed that persistent high niacin intake, whether through fortified foods or supplements, raises the risk of cardiovascular disease by elevating the metabolite 4PY. The study further suggests that similar risks are associated with NR and NMN supplements. While supplementation is recommended for correcting NAD deficiency, the study emphasizes the crucial importance of monitoring NAD levels through regular measurements. NADMED offers established healthy ranges for NAD levels to guide optimal supplementation intake.

The study was published in Nature Medicine. Read more here.